Psoriasis and Interaction with Simvastatin as Adjuvant Therapy

Abstract

Psoriasis is a common, chronic inflammatory skin disease, mediated by immune system, with common comorbidities are metabolic syndrome and cardiovascular disease, associated with fat metabolism. One component of fat is cholesterol, an essential lipophilic molecule for humans. The structure of cholesterol is divided into three, hydrophobic, hydrophilic, and rigid structures, allowing cholesterol to regulate various cellular processes in the body. Cholesterol made by cell in the body mostly, and the rest is obtained from food. There is a complex relationship between cholesterol metabolism and psoriasis. Dysregulation of cholesterol metabolism affects keratinocyte function and then worsens psoriasis lesions. Antipsoriasis drugs have varying effects on cholesterol, while statins, cholesterol-lowering drugs, have a good effect on psoriasis patients. Simvastatin has a good effect on psoriasis patients. Using simvastatin as an adjuvant therapy for psoriasis is a good choice to get a better results and long remition time.