Development of Beta-Carotene Extract and Caffeine Hydrogel-Based for Wound Healing

Abstract

The skin, as the largest organ in the human body, plays a vital role in protecting the body from external damage and microbial invasion, while maintaining the balance of fluids, electrolytes, and essential nutrients. Skin injuries, often resulting from accidents, can lead to wounds that require prompt healing to prevent complications and infections. The use of preparation containing natural antioxidant agents is an essential part of wound care. Recent studies continue to explore various materials for wound healing, with hydrogels emerging as an effective delivery system due to their unique properties. This study aims to formulate a beta-carotene hydrogel and caffeine polymer-based topical gel for wound healing and protection. The objectives of this research are to evaluate the physical properties, pH, viscosity, and spreadability of the hydrogel over a storage period of 28 and 56 days. Additionally, the study investigates wound healing effectiveness in animal models 28 rats are divided into three groups, each containing 4 rats. by assessing the healing time, collagen formation, Ephitalization, and fibroblast over a 3-week period. The results analyzed using ANOVA, with a significance level of p < 0.05. Previous research has demonstrated that beta-carotene, isolated from carrot extracts, and nano-caffeine formulations have shown promising results in wound healing. The findings of this study are expected to contribute valuable insights into the development of effective topical treatments. This research offers a potential advancement in the field of wound care and topical drug delivery systems.